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AstraZeneca recruits individuals for KODIAC Stage III trial in opioid-induced constipation AstraZeneca today announced that research centers over the U.S. Are recruiting sufferers for a clinical research to examine whether an investigational medication is effective and safe in treating opioid-induced constipation . The scholarly study, known as KODIAC, is certainly a Phase III medical trial examining an investigational medication in sufferers experiencing constipation because of opioid use, that is a potential side-effect of prescription opioid discomfort medicines.