CRI scientists identify crisis blood-formation system in the physical body Scientists at the Kids's Medical Center Research Institute at UT Southwestern have determined the way the body responds during moments of crisis when it requires more blood cells. In a scholarly study published in Nature, researchers report that when injury occurs, in instances of extreme bleeding, or during being pregnant, a second, emergency blood-formation system can be activated in the spleen. ‘Hematopoietic, or blood-forming, stem cells reside in the bone marrow primarily, and most new bloodstream cell formation takes place within the bone marrow under normal circumstances .

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Mills speculates that when levels of TAp63 drop beneath a certain threshold, it is no more protective, opening the best way to pathology. ‘The only way you could have the EEC mutation and become normal, or have minor symptoms of the illness such as a bit of webbing between two toes, is to have robust amounts of TAp63 proteins in cells when and where it is needed, during advancement,’ says Mills. She expectations that her team's discovery that TAp63 affects the presence of birth defects will encourage doctors treating children with EEC to review those just mildly affected with siblings or other children who have a severe form of the disease. ‘It will be vital that you sequence DNA from these kids and compare the outcomes. What's different? If we find variations, we’ve nailed it.