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However, when both VEGF and c-MET signaling had been inhibited simultaneously, there was a decrease in metastasis and invasion. The experts tested three c-MET inhibitors: crizotinib and PF-04217903, which target c-MET however, not VEGF signaling, and cabozantinib, a dual inhibitor that blocks VEGF and c-MET signaling. McDonald said they conducted their initial study in neuroendocrine pancreatic tumors because the genetic mouse model of these tumors has been studied so extensively, and observed the result in other tumors as well then.