Also, among individuals with very regular flare-ups of disease despite bronchodilator therapy, it can appear to be that having inhaled steroids within their treatment regime, with a long-acting beta-agonist generally, really helps to reduce exacerbation also. There is also roflumilast, which is a PDE-4 inhibitor which has not had broad uptake yet around the world, but again seems to reduce exacerbations in people who have COPD.Among these saccharides would be a appropriate antigen. However, attempts to implement saccharides as the foundation for a vaccine have thus far failed; regrettably, carbohydrates can easily activate B-lymphocytes, but not T-lymphocytes. For successful immunization, the cooperation of both types of cells is needed. It is helpful to couple the sugar to a foreign carrier protein, but this is a controllable reaction whose products may also trigger undesired immunological effects poorly. Related StoriesCornell biomedical engineers develop 'super organic killer cells' to destroy cancer cells in lymph nodesStudy displays rare HER2 missense mutations do not spread breast cancer on the ownNew RNA check of blood platelets can be used to detect area of cancerThe research team headed by Geert-Jan Boons at the University of Georgia in Athens has found a clever alternative: They have synthesized a three-component vaccine.