De Camilli laboratory extensively cycling the mechanism of synaptic vesicles, examined the little bags with neurotransmitters that the exchange of information between nerve cells . Synaptic vesicles release their contents at junctions between nerve terminals by fusing with the plasma membrane, where they internalize quickly , reload with neurotransmitter and reused.

The researchers genetically laboratory mice lacking the enzyme gamma – PIPK1 developed at the synapse. This enzyme plays an important role in the synthesis of PtdIns P2 and a partial impairment of both of the process of fusion of synaptic vesicles and their recycling.

Was found to remain at the bottom line, surgery lead to less complication , but it requires on average one longer in the hospital.